Influence of the association between simvastatin and demineralized bovine bone matrix on bone repair in rats

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Influence of the association between simvastatin and demineralized bovine bone matrix on bone repair in rats.

Simvastatin, a drug used to lower blood cholesterol, has been reported to have an anabolic effect on bone. The purpose of this study was to evaluate the influence of simvastatin and demineralized bovine bone matrix (DBBM) on the repair of rat calvarial defects. Defects of 5 mm were created in 64 rats, divided into four groups: no local treatment (control); treatment with DBBM (DBBM); treatment ...

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Influence of fluvastatin on bone formation induced by demineralized bone matrix in mice.

In the last decade, statins became widely used drugs in hypercholesterolemia treatment. Several studies have demonstrated that statins may also be successfully administered in the treatment of osteoporosis. There are, however, no reports regarding the effect of statins on heterotopic ossification (HO). In this paper, we examined the influence of fluvastatin on heterotopically induced bone forma...

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Demineralized bone matrix used for direct pulp capping in rats

OBJECTIVES To evaluate the wound healing process following direct pulp capping with demineralized bone matrix (DBM) and calcium hydroxide (Ca(OH)2). METHODS Fifty 8-weeks-old SPF Wistar male rats were divided into two groups: one was the DBM treated group, and the other was the Ca(OH)2 treated group. Pulpotomy was performed on the maxillary first molar of one side of each rat, and the another...

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histologic effects of demineralized bone matrix on regeneration of alveolar socket in diabetic rats

introduction: the aim of this in vivo study was to determine the effect of demineralized bone matrix (dbm) on alveolar bone repair in type i diabetic rats. materials and methods: this study was carried out on 40 adult (8 weeks-old) albino rats with an average weight of 200-250 grams. the animals were divided into four groups (n=10) as follows: group 1 nondiabetic rats, group 2, 3 and 4 were dia...

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Demineralized bone matrix and spinal arthrodesis.

Spinal fusion is a gold-standard treatment for many disorders of the spine with autogenous bone graft as the gold-standard source for augmenting fusion. However, the morbidity and limitations of autogenous bone grafting has motivated the search for bone graft alternatives. One such alternative is demineralized bone matrix (DBM). The purpose of this paper is to describe and characterize the prop...

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ژورنال

عنوان ژورنال: Brazilian Oral Research

سال: 2011

ISSN: 1806-8324

DOI: 10.1590/s1806-83242011000100008